Label-Free Detection Market Product & Service, Technology, Application, End User – Global Forecast 2021 – 2028

Effect of COVID-19 on the global market for label-free detection

Researchers from ETH Zurich (Switzerland) claim that when used to detect COVID-19 RNA, Localized Surface Plasmon Resonance (LSPR) displayed a high level of accuracy and sensitivity. One of the key technologies used in label-free detection is surface plasmon resonance. This is a key sign of market expansion. Additionally, label-free goods like SPR systems and biosensors are employed in COVID-19 research. R&D labs, however, are currently only operating at 50% of their normal capacity. Approximately 44% of the 2522 clinical trial registry entries that were suspended, terminated, or withdrawn between December 1, 2019, and May 5, 2020 were closed with a reported reason that explicitly mentioned COVID-19, according to an analysis of studies based on These elements might prevent the market from expanding.

Dynamics of the Label-Free Detection Market

Label-free technologies, which are still relatively new in the well-established field of high-throughput screening (HTS), offer chances to probe biomolecular interactions without the effects of labels’ auto-fluorescence or quenching.

A new drug must travel from its initial discovery to the market for at least ten years on average. According to estimates, each successful drug requires an average investment of USD 2.6 billion in research and development (PhRMA). It has been difficult to increase productivity in early drug discovery processes due to mounting cost pressures and more complex disease targets.

Limitation: Exorbitant instrument prices

Label-free detection equipment is very expensive because it has high-end features and functionalities. An average Bio-layer interferometry system costs between 50,000 and 300,000 dollars. The cost of Agilent’s (US) xCELLigence systems ranges from USD 50,000 to USD 500,000, depending on features like throughput. They are available for both academia and the industrial sector. These instruments are not affordable for businesses with smaller R&D budgets, which is a significant barrier to market expansion. Budget restrictions make it difficult for academic research laboratories to purchase these tools. Additionally, label-free platforms are only available in well-funded labs and academic core labs due to the high capital and operating costs, as well as the weekly maintenance costs of SPR systems. SPR platforms are not appropriate for multi-user laboratories because they are difficult to operate.

Contrarily, pharmaceutical firms use LFD instruments the most and have relatively larger R&D budgets; however, their need for numerous such instruments increases capital costs. Because LFD instruments are expensive, there may not be as much demand for them, which could impede the expansion of the market as a whole.

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Growing life science research in emerging markets presents an opportunity.

The label-free detection market in Asia is primarily driven by growth in the Asian economies, particularly China and India, as well as increased investments in biotechnology and drug discovery. Although the majority of Asian nations currently lack established business models, they have the scientific talent to create robust domestic biotechnology industries. As a result, there are more mergers, partnerships, and collaborations taking place in these developing nations. In order to encourage investments, innovation, and commercialization, many Asian economies have altered their rules, regulations, and policies. As a result, research efforts in the life sciences sector are increasing.

Problem: A lack of qualified professionals

Label-free detection is a relatively new technique, so professionals with a variety of skill sets and solid instrument and software operating experience are needed. A label-free experiment needs to be set up and performed by competent workers on many of the highly automated, high-throughput devices. Researchers with experience using label-free detection equipment are in high demand in both research labs and businesses.

The biosensor chips category accounted for the greatest share of the label-free detection market in terms of consumables in 2019.

The consumables market is divided into biosensor chips, microplates, and reagents & kits based on the type of product & service it offers. Due to its high specificity and capacity to track chemical interactions in real-time, biosensor chips held the highest proportion of the consumables market in 2019.

In terms of end users, pharmaceutical and biotechnology firms held the greatest market share for label-free detection in 2019.

The label-free detection market has been divided into different end users based on their end use, including pharmaceutical and biotechnology firms, academic and research institutions, contract research organisations (CROs), and other end users in the food and beverage, agriculture and livestock, oil and gas, environmental monitoring, chemicals, bioplastics, and cosmeceuticals industries. Due to their widespread use of label-free detection technologies for researching biomolecular interactions in drug discovery, pharmaceutical and biotechnology firms held the majority of the market share for label-free detection in 2019.

In 2019, North America held the greatest market share for label-free detection.

The highest market share in 2019 belonged to North America, followed by Europe. The main drivers of the North American market are the availability of research funding, rising research activity in drug discovery and development, rise in pharmaceutical R&D spending, and the existence of important players.

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 The study categorizes the label free detection market into the following segments and subsegments:

Label-free detection Market, by Product & Service

  • Instruments
  • Consumables
    • Biosensor Chips
    • Microplates
    • Reagents & Kits
  • Software & Services

Label-free detection Market, by Technology

  • Surface Plasmon Resonance
  • Bio-layer Interferometry
  • Isothermal Titration Calorimetry
  • Differential Scanning Calorimetry
  • Other LFD Technologies

Label-free detection Market by Application

  • Binding Kinetics
  • Hit Confirmation
  • Lead Generation
  • Endogenous Receptor Detection
  • Binding Thermodynamics
  • Other Applications

Label-free detection Market, by End User

  • Pharmaceutical and Biotechnology Companies
  • Academic and Research Institutes
  • Contract Research Organizations (CROs)
  • Other End Users

Label-free detection Market, by Region

  • North America
    • US
    • Canada
  • Europe
    • Germany
    • UK
    • France
    • Italy
    • Spain
    • Rest of Europe
  • Asia Pacific
    • China
    • Japan
    • India
    • Rest of Asia Pacific
  • Rest of the World
    • Latin America
    • The Middle East and Africa

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